The recent development in Artificial Intelligence (AI) in epigenetics and genome editing is very impressive. AI has been found to be an effective tool to revolutionize the health care industry. AI can be used to develop predictive models to identify diseases such as cancer. Another noteworthy feature of AI is to predict the most effective treatment for the patients. Predictive models for treatment response can also be achieved by AI. By using medical history and genetics, AI can accurately predict the treatment options for each patients allowing doctors to tailor treatment plans. AI is an effective tool to personalize the medicine recommendation for improving health and preventing diseases. Overall, AI has the potential in genome editing, disease prognosis, predictive and personalized medicine to the particular diseases so that it revolutionizes the health care.