Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic chemicals widely used in industrial and consumer applications for their hydrophobicity and chemical stability. These “forever chemicals” are persistent in the environment and have been increasingly detected in aquatic ecosystems and seafood, posing risks to food safety and public health. This review synthesizes current knowledge on PFAS chemical properties, contamination pathways in marine and aquaculture environments, and their bioaccumulation in seafood species. It also explores remediation technologies – including adsorption, ion exchange, membrane filtration, and advanced oxidation processes – alongside challenges in implementation. The review concludes by highlighting the need for integrated monitoring, regulatory controls, and risk mitigation strategies to address the global threat of PFAS in aquatic food systems.